Endocrine Abstracts

Sixty six year old gentleman was referred to clinic with hypercalcaemia. He suffered with low mood, “funny turns”, nocturia and loose stools with urgency to open bowels. He appeared tanned but no increase pigmentation in skin folds. There was no palpable lymphadenopathy or neck lump. The calcium levels were around three with low normal PTH of 3.7 (2.8 on repeat). He had not developed any complications like osteoporosis, fracture or renal stones secondary to hypercalc...

Introduction: British Thyroid Association Guidelines state that the diagnosis of thyroid malignancy cannot be based on the results of an aspiration’s cytology alone and will usually require surgical removal for confirmation. There has been much debate about the management of indeterminate fine needle aspirations (Thy 3). Recent publications have reported that the prevalence of thyroid carcinoma following a Thy 3 result to be as high has 28%, emphasising the importance of ...

A key component of androgen synthesis is the availability of the pro-hormone DHEA, which is either converted to active androgens or inactivated to its sulfate ester DHEAS by DHEA sulfotransferase (SULT2A1). The latter reaction requires provision of the universal sulfate donor 3′-phosphoadenosine-5′-phosphosulfate, PAPS. In humans, PAPS is generated by the PAPS synthase isoforms PAPSS1 and PAPSS2. Recently, inactivating PAPSS2 mutations have been identified i...